Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC3630832 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zhou Yufeng Y Tung Hui-Ying HY Tsai Ying-Ming YM Hsu Shih-Chang SC Chang Hui-Wen HW Kawasaki Hirokazu H Tseng Hsiao-Chun HC Plunkett Beverly B Gao Peisong P Hung Chih-Hsing CH Vonakis Becky M BM Huang Shau-Ku SK
Blood 20130305 16
We propose that the aryl hydrocarbon receptor (AhR), a unique chemical sensor, is critical in controlling mast cell differentiation, growth, and function in vitro and in vivo. In antigen-stimulated mast cells, exposure to AhR ligands resulted in a calcium- and reactive oxygen species (ROS)-dependent increase of reversible oxidation in and reduced activity of SHP-2 phosphatase, leading to enhanced mast cell signaling, degranulation, and mediator and cytokine release, as well as the in vivo anaphy ...[more]