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ABSTRACT: Objective
To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD).Design
Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study).Participants
A total of 2599 AMD cases and 3458 ethnically matched controls.Methods
Fifteen single nucleotide polymorphisms (SNPs) spanning the C5 gene were initially genotyped in 375 cases and 199 controls from The Netherlands (The Amsterdam/Rotterdam-Netherlands [AMRO-NL] study population). Replication testing of selected SNPs was performed in the Rotterdam Study (NL) and study populations from Southampton, United Kingdom (UK), and New York, United States (US).Main outcome measures
Early and late stages of prevalent and incident AMD, graded according to (a modification of) the international grading and classification system of AMD.Results
Significant allelic or genotypic associations between 8 C5 SNPs and AMD were found in the AMRO-NL study and this risk seemed to be independent of CFH Y402H, LOC387715 A69S, age, and gender. None of these findings could be confirmed consistently in 3 replication populations.Conclusions
Although the complement pathway, including C5, plays a crucial role in AMD, and the C5 protein is present in drusen, no consistent significant associations between C5 SNPs and AMD were found in any of these studies. The implications for genetic screening of AMD are discussed.
SUBMITTER: Baas DC
PROVIDER: S-EPMC2830367 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Baas Dominique C DC Ho Lintje L Ennis Sarah S Merriam Joanna E JE Tanck Michael W T MW Uitterlinden André G AG de Jong Paulus T V M PT Cree Angela J AJ Griffiths Helen L HL Rivadeneira Fernando F Hofman Albert A van Duijn Cornelia C Smith R Theodore RT Barile Gaetano R GR Gorgels Theo G M F TG Vingerling Johannes R JR Klaver Caroline C W CC Lotery Andrew J AJ Allikmets Rando R Bergen Arthur A B AA
Ophthalmology 20091222 3
<h4>Objective</h4>To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD).<h4>Design</h4>Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study).<h4>Participants</h4>A total of 2599 AMD cases and 3458 ethnically matched controls.<h4>Methods</h4>Fifteen single nucleotide polymorphisms (SNPs) spanning the C5 gene were initially genotyped in 375 cases an ...[more]