Ontology highlight
ABSTRACT:
SUBMITTER: Thiery J
PROVIDER: S-EPMC2830763 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Thiery Jerome J Keefe Dennis D Saffarian Saviz S Martinvalet Denis D Walch Michael M Boucrot Emmanuel E Kirchhausen Tomas T Lieberman Judy J
Blood 20091228 8
Cytotoxic T lymphocytes and natural killer cells destroy target cells via the polarized exocytosis of lytic effector proteins, perforin and granzymes, into the immunologic synapse. How these molecules enter target cells is not fully understood. It is debated whether granzymes enter via perforin pores formed at the plasma membrane or whether perforin and granzymes are first endocytosed and granzymes are then released from endosomes into the cytoplasm. We previously showed that perforin disruption ...[more]