Ontology highlight
ABSTRACT:
SUBMITTER: Tiedemann RE
PROVIDER: S-EPMC2830764 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Tiedemann Rodger E RE Zhu Yuan Xiao YX Schmidt Jessica J Yin Hongwei H Shi Chang-Xin CX Que Qiang Q Basu Gargi G Azorsa David D Perkins Louise M LM Braggio Esteban E Fonseca Rafael R Bergsagel P Leif PL Mousses Spyro S Stewart A Keith AK
Blood 20091207 8
A paucity of validated kinase targets in human multiple myeloma has delayed clinical deployment of kinase inhibitors in treatment strategies. We therefore conducted a kinome-wide small interfering RNA (siRNA) lethality study in myeloma tumor lines bearing common t(4;14), t(14;16), and t(11;14) translocations to identify critically vulnerable kinases in myeloma tumor cells without regard to preconceived mechanistic notions. Fifteen kinases were repeatedly vulnerable in myeloma cells, including AK ...[more]