Ontology highlight
ABSTRACT:
SUBMITTER: Duong-Ly KC
PROVIDER: S-EPMC4128285 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Duong-Ly Krisna C KC Peterson Jeffrey R JR
Current protocols in pharmacology 20130301
Protein and lipid kinases play key regulatory roles in a number of biological processes. Unsurprisingly, activating mutations in kinases have been linked to a number of disorders and diseases, most notably cancers. Thus, kinases have emerged as promising clinical targets. There are more than 500 human protein kinases and about 20 lipid kinases. Most protein kinases share a highly conserved domain, the eukaryotic protein kinase (ePK) domain, which contains the ATP and substrate-binding sites. Man ...[more]