Ontology highlight
ABSTRACT:
SUBMITTER: Javvadi P
PROVIDER: S-EPMC2831122 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Javvadi Prashanthi P Hertan Lauren L Kosoff Rachelle R Datta Tatini T Kolev Johann J Mick Rosemarie R Tuttle Stephen W SW Koumenis Constantinos C
Cancer research 20100216 5
Curcumin, a plant polyphenol, is a widely studied chemopreventive agent with demonstrated antitumor activities in preclinical studies and low toxicity profiles in multiple clinical trials against human malignancies. We previously showed that curcumin radiosensitizes cervical tumor cells without increasing the cytotoxic effects of radiation on normal human fibroblasts. Here we report that an inhibitory activity of curcumin on the antioxidant enzyme thioredoxin reductase-1 (TxnRd1) is required for ...[more]