Ontology highlight
ABSTRACT:
SUBMITTER: Qiu C
PROVIDER: S-EPMC2831306 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Qiu Caihong C Ma Yinghong Y Wang Jianquan J Peng Shuping S Huang Yingqun Y
Nucleic acids research 20091204 4
Lin28 acts as a repressor of microRNA processing and as a post-transcriptional regulatory factor for a subset of mRNAs. Here we report that in human embryonic stem cells Lin28 facilitates the expression of the pivotal pluripotency factor Oct4 at the post-transcriptional level. We provide evidence that Lin28 binds Oct4 mRNA directly through high affinity sites within its coding region and that an interaction between Lin28 and RNA helicase A (RHA) may play a part in the observed regulation. We fur ...[more]