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A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.

ABSTRACT: Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity.

SUBMITTER: Salzameda NT

PROVIDER: S-EPMC3065946 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action.

Salzameda Nicholas T NT Eubanks Lisa M LM Zakhari Joseph S JS Tsuchikama Kyoji K DeNunzio Nicholas J NJ Allen Karen N KN Hixon Mark S MS Janda Kim D KD

Chemical communications (Cambridge, England) 20110104 6

Clostridium botulinum produces the most lethal toxins known to man, as such they are high risk terrorist threats, and alarmingly there is no approved therapeutic. We report the first cross-over small molecule inhibitor of these neurotoxins and propose a mechanism by which it may impart its inhibitory activity. ...[more]

PMID: 21203627

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