Ontology highlight
ABSTRACT:
SUBMITTER: Singh SK
PROVIDER: S-EPMC2832577 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Singh Satinder K SK Piscitelli Chayne L CL Yamashita Atsuko A Gouaux Eric E
Science (New York, N.Y.) 20081201 5908
Secondary transporters are workhorses of cellular membranes, catalyzing the movement of small molecules and ions across the bilayer and coupling substrate passage to ion gradients. However, the conformational changes that accompany substrate transport, the mechanism by which a substrate moves through the transporter, and principles of competitive inhibition remain unclear. We used crystallographic and functional studies on the leucine transporter (LeuT), a model for neurotransmitter sodium sympo ...[more]