Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3322350 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Wang Hui H Elferich Johannes J Gouaux Eric E
Nature structural & molecular biology 20120115 2
Neurotransmitter sodium symporters (NSSs) catalyze the uptake of neurotransmitters into cells, terminating neurotransmission at chemical synapses. Consistent with the role of NSSs in the central nervous system, they are implicated in multiple diseases and disorders. LeuT, from Aquifex aeolicus, is a prokaryotic ortholog of the NSS family and has contributed to our understanding of the structure, mechanism and pharmacology of NSSs. At present, however, the functional state of LeuT in crystals gro ...[more]