The adenovirus type 3 dodecahedron's RGD loop comprises an HSPG binding site that influences integrin binding.
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ABSTRACT:
SUBMITTER: Gout E
PROVIDER: S-EPMC2833306 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Publications
The adenovirus type 3 dodecahedron's RGD loop comprises an HSPG binding site that influences integrin binding.
Gout E E Schoehn G G Fenel D D Lortat-Jacob H H Fender P P
Journal of biomedicine & biotechnology 20100304
Human type 3 adenovirus dodecahedron (a virus like particle made of twelve penton bases) features the ability to enter cells through Heparan Sulphate Proteoglycans (HSPGs) and integrins interaction and is used as a versatile vector to deliver DNA or proteins. Cryo-EM reconstruction of the pseudoviral particle with Heparan Sulphate (HS) oligosaccharide shows an extradensity on the RGD loop. A set of mutants was designed to study the respective roles of the RGD sequence (RGE mutant) and of a basic ...[more]
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