Ontology highlight
ABSTRACT:
SUBMITTER: Schurpf T
PROVIDER: S-EPMC3405271 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Schürpf Thomas T Chen Qiang Q Liu Jin-Huan JH Wang Rui R Springer Timothy A TA Wang Jia-Huai JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120517 8
Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin α(V)β(3). Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF ...[more]