Investigation of the sequence and length dependence for cell-penetrating prenylated peptides.
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ABSTRACT:
SUBMITTER: Wollack JW
PROVIDER: S-EPMC2834556 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Investigation of the sequence and length dependence for cell-penetrating prenylated peptides.
Wollack James W JW Zeliadt Nicholette A NA Ochocki Joshua D JD Mullen Daniel G DG Barany George G Wattenberg Elizabeth V EV Distefano Mark D MD
Bioorganic & medicinal chemistry letters 20091113 1
Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this study a series of such peptides was synthesized to examine the relationship between peptide sequence and level of peptide internalization and to probe their mechanism of internalization. This study revealed that prenylated peptides internalize via a non-endocytotic pathway regardle ...[more]
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