Ontology highlight
ABSTRACT:
SUBMITTER: Atanasijevic T
PROVIDER: S-EPMC2834819 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Atanasijevic Tatjana T Zhang Xiao-an XA Lippard Stephen J SJ Jasanoff Alan A
Inorganic chemistry 20100301 6
We introduce a mechanism for ion sensing by MRI in which analytes compete with paramagnetic ions for binding to polydentate chelating agents. Displacement of the paramagnetic ions results in alteration of solvent interaction parameters and consequent changes in relaxivity and MRI contrast. The MRI changes can be tuned by the choice of chelator. As an example, we show that calcium-dependent displacement of Mn(2+) ions bound to EGTA and BAPTA results in a T(1)-weighted MRI signal increase, whereas ...[more]