Ontology highlight
ABSTRACT:
SUBMITTER: Barandov A
PROVIDER: S-EPMC6385297 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Barandov Ali A Bartelle Benjamin B BB Williamson Catherine G CG Loucks Emily S ES Lippard Stephen J SJ Jasanoff Alan A
Nature communications 20190222 1
Calcium ions are essential to signal transduction in virtually all cells, where they coordinate processes ranging from embryogenesis to neural function. Although optical probes for intracellular calcium imaging have been available for decades, the development of probes for noninvasive detection of intracellular calcium signaling in deep tissue and intact organisms remains a challenge. To address this problem, we synthesized a manganese-based paramagnetic contrast agent, ManICS1-AM, designed to p ...[more]