Ontology highlight
ABSTRACT:
SUBMITTER: Pal SK
PROVIDER: S-EPMC283492 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Pal Samir Kumar SK Zhao Liang L Xia Tianbing T Zewail Ahmed H AH
Proceedings of the National Academy of Sciences of the United States of America 20031105 24
Water molecules in the DNA grooves are critical for maintaining structural integrity, conformational changes, and molecular recognition. Here we report studies of site- and sequence-specific hydration dynamics, using 2-aminopurine (Ap) as the intrinsic fluorescence probe and with femtosecond resolution. The dodecamer d[CGCA(Ap)ATTTGCG]2 was investigated, and we also examined the effect of a specific minor groove-binding drug, pentamidine, on hydration dynamics. Two time scales were observed: app ...[more]