Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez EM
PROVIDER: S-EPMC7309323 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Organic letters 20200407 12
Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO<sub>2</sub><sup>2-</sup>. ...[more]