Differences in DBA/1J and DBA/2J reveal lipid QTL genes.
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ABSTRACT:
SUBMITTER: Stylianou IM
PROVIDER: S-EPMC2834962 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Differences in DBA/1J and DBA/2J reveal lipid QTL genes.
Stylianou Ioannis M IM Langley Sarah R SR Walsh Kenneth K Chen Yuan Y Revenu Céline C Paigen Beverly B
Journal of lipid research 20080523 11
Recent advances in mouse genomics have revealed considerable variation in the form of single-nucleotide polymorphisms (SNPs) among common inbred strains. This has made it possible to characterize closely related strains and to identify genes that differ; such genes may be causal for quantitative phenotypes. The mouse strains DBA/1J and DBA/2J differ by just 5.6% at the SNP level. These strains exhibit differences in a number of metabolic and lipid phenotypes, such as plasma levels of triglycerid ...[more]
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