Ontology highlight
ABSTRACT:
SUBMITTER: Ferras C
PROVIDER: S-EPMC2835239 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Ferrás Cristina C Oude Vrielink Joachim A F JA Verspuy Johan W A JW te Riele Hein H Tsaalbi-Shtylik Anastasia A de Wind Niels N
Molecular therapy : the journal of the American Society of Gene Therapy 20090526 8
A substantial fraction of sporadic and inherited colorectal and endometrial cancers in humans is deficient in DNA mismatch repair (MMR). These cancers are characterized by length alterations in ubiquitous simple sequence repeats, a phenotype called microsatellite instability. Here we have exploited this phenotype by developing a novel approach for the highly selective gene therapy of MMR-deficient tumors. To achieve this selectivity, we mutated the VP22FCU1 suicide gene by inserting an out-of-fr ...[more]