Ontology highlight
ABSTRACT:
SUBMITTER: Kumar S
PROVIDER: S-EPMC283559 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Kumar Sanjeev S Christophides George K GK Cantera Rafael R Charles Bradley B Han Yeon Soo YS Meister Stephan S Dimopoulos George G Kafatos Fotis C FC Barillas-Mury Carolina C
Proceedings of the National Academy of Sciences of the United States of America 20031117 24
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks Plasmodium development, melanizing, and encapsulating the parasite in a reaction that begins with tyrosine oxidation, and involves three quantitative trait loci. Morphological and microarray mRNA expression analysis suggest that the refractory and susceptible strains have broad physiological difference ...[more]