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Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.

ABSTRACT: The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in?vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O₂ ^.- produced by the PDT is converted to H₂ O₂ by superoxide dismutase, followed by the transformation of H₂ O₂ to the highly toxic ^. OH via Fenton reactions by Fe²⁺ originating from the dissolution of co-loaded Fe₃ O₄ nanoparticles. The PDT process further facilitates the endosomal/lysosomal escape of the active agents and enhances their intracellular delivery to the nucleus-even for drug-resistant cells. Cisplatin generates O₂ ^.- in the presence of nicotinamide adenine dinucleotide phosphate oxidase and thereby improves the treatment efficiency by serving as an additional O₂ ^.- source for production of ^. OH radicals. Improved anticancer efficiency is achieved under both hypoxic and normoxic conditions.

SUBMITTER: Jiang S

PROVIDER: S-EPMC7693068 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.

Jiang Shuai S Xiao Ming M Sun Wen W Crespy Daniel D Mailänder Volker V Peng Xiaojun X Fan Jiangli J Landfester Katharina K

Angewandte Chemie (International ed. in English) 20200915 45

The anticancer efficacy of photodynamic therapy (PDT) is limited due to the hypoxic features of solid tumors. We report synergistic PDT/chemotherapy with integrated tandem Fenton reactions mediated by ovalbumin encapsulation for improved in vivo anticancer therapy via an enhanced reactive oxygen species (ROS) generation mechanism. O2.- produced by the PDT is converted to H2 O2 by superoxide dismutase, followed by the transformation of H2 O<s ...[more]

PMID: 32686218

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Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.

Publications

Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation.

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