Ontology highlight
ABSTRACT:
SUBMITTER: Fritton JC
PROVIDER: S-EPMC2836075 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Fritton J Christopher JC Kawashima Yuki Y Mejia Wilson W Courtland Hayden-Williams HW Elis Sebastien S Sun Hui H Wu Yinjgie Y Rosen Clifford J CJ Clemmons David D Yakar Shoshana S
The Journal of biological chemistry 20091210 7
Age-related osteoporosis is accompanied by an increase in marrow adiposity and a reduction in serum insulin-like growth factor-1 (IGF-1) and the binding proteins that stabilize IGF-1. To determine the relationship between these proteins and bone marrow adiposity, we evaluated the adipogenic potential of marrow-derived mesenchymal stromal cells (MSCs) from mice with decreased serum IGF-1 due to knockdown of IGF-1 production by the liver or knock-out of the binding proteins. We employed 10-16-week ...[more]