Ontology highlight
ABSTRACT:
SUBMITTER: Liao Y
PROVIDER: S-EPMC5112041 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Liao Yan Y Lei Junxia J Liu Muyun M Lin Wanwen W Hong Dongxi D Tuo Ying Y Jiang Mei Hua MH Xia Huimin H Wang Maosheng M Huang Weijun W Xiang Andy Peng AP
Molecular therapy : the journal of the American Society of Gene Therapy 20160709 10
Mesenchymal stromal cells (MSCs) have shown great potential for treating inflammatory bowel disease, which is ameliorated through paracrine cross talk between MSCs and T-cells. Members of the insulin-like growth factor binding protein (IGFBP) family have important immunomodulatory functions in MSCs, but the underlying mechanisms behind these functions have not yet been clearly elucidated. In this study, we investigate whether MSC-produced IGFBP7 is involved in immune modulation using a mouse exp ...[more]