Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC2836843 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wang Lei L Cherian Christina C Desmoulin Sita Kugel SK Polin Lisa L Deng Yijun Y Wu Jianmei J Hou Zhanjun Z White Kathryn K Kushner Juiwanna J Matherly Larry H LH Gangjee Aleem A
Journal of medicinal chemistry 20100201 3
2-Amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines with a thienoyl side chain and four to six carbon bridge lengths (compounds 1-3) were synthesized as substrates for folate receptors (FRs) and the proton-coupled folate transporter (PCFT). Conversion of acetylene carboxylic acids to alpha-bromomethylketones and condensation with 2,4-diamino-6-hydroxypyrimidine afforded the 6-substituted pyrrolo[2,3-d]pyrimidines. Sonogashira coupling with (S)-2-[(5-bromo-thiophene-2-carbonyl)-amino]-pentanedi ...[more]