Ontology highlight
ABSTRACT:
SUBMITTER: Li XS
PROVIDER: S-EPMC2838063 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Li Xuan Shirley XS Trojer Patrick P Matsumura Tatsushi T Treisman Jessica E JE Tanese Naoko N
Molecular and cellular biology 20100119 7
The mammalian SWI/SNF chromatin-remodeling complex facilitates DNA access by transcription factors and the transcription machinery. The characteristic member of human SWI/SNF-A is BAF250/ARID1, of which there are two isoforms, BAF250a/ARID1a and BAF250b/ARID1b. Here we report that BAF250b complexes purified from mammalian cells contain elongin C (Elo C), a BC box binding component of an E3 ubiquitin ligase. BAF250b was found to have a BC box motif, associate with Elo C in a BC box-dependent mann ...[more]