Ontology highlight
ABSTRACT:
SUBMITTER: Maitland MER
PROVIDER: S-EPMC6614414 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Maitland Matthew E R MER Onea Gabriel G Chiasson Christopher A CA Wang Xu X Ma Jun J Moor Sarah E SE Barber Kathryn R KR Lajoie Gilles A GA Shaw Gary S GS Schild-Poulter Caroline C
Scientific reports 20190708 1
The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the human CTLH complex and characterized its E3 ligase activity. We confirm that the complex immunoprecipitated from human cells comprises RanBPM, ARMC8 α/β, muskelin, WDR26, GID4 and the RING domain proteins RMND5A and MAEA. We find that loss of expression of individual subunits compromises the stability of other complex members and that MAE ...[more]