Ontology highlight
ABSTRACT:
SUBMITTER: Ma D
PROVIDER: S-EPMC2838284 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Ma Dongzhu D Bai Xiaochun X Zou Huafei H Lai Yumei Y Jiang Yu Y
The Journal of biological chemistry 20100104 12
FKBP38 is a member of the family of FK506-binding proteins that acts as an inhibitor of the mammalian target of rapamycin (mTOR). The inhibitory action of FKBP38 is antagonized by Rheb, an oncogenic small GTPase, which interacts with FKBP38 and prevents its association with mTOR. In addition to the role in mTOR regulation, FKBP38 is also involved in binding and recruiting Bcl-2 and Bcl-X(L), two anti-apoptotic proteins, to mitochondria. In this study, we investigated the possibility that Rheb co ...[more]