Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC2838304 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Liu Zhuo Z Lin Lin L Yuan Cai C Nicolaes Gerry A F GA Chen Liqing L Meehan Edward J EJ Furie Bruce B Furie Barbara B Huang Mingdong M
The Journal of biological chemistry 20100120 12
Factor VIII (FVIII) plays a critical role in blood coagulation by forming the tenase complex with factor IXa and calcium ions on a membrane surface containing negatively charged phospholipids. The tenase complex activates factor X during blood coagulation. The carboxyl-terminal C2 domain of FVIII is the main membrane-binding and von Willebrand factor-binding region of the protein. Mutations of FVIII cause hemophilia A, whereas elevation of FVIII activity is a risk factor for thromboembolic disea ...[more]