Ontology highlight
ABSTRACT:
SUBMITTER: Zhou XE
PROVIDER: S-EPMC2838335 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Zhou X Edward XE Suino-Powell Kelly M KM Li Jun J He Yuanzheng Y Mackeigan Jeffrey P JP Melcher Karsten K Yong Eu-Leong EL Xu H Eric HE
The Journal of biological chemistry 20100119 12
Transcription activation by androgen receptor (AR), which depends on recruitment of coactivators, is required for the initiation and progression of prostate cancer, yet the mechanisms of how hormone-activated AR interacts with coactivators remain unclear. This is because AR, unlike any other nuclear receptor, prefers its own N-terminal FXXLF motif to the canonical LXXLL motifs of coactivators. Through biochemical and crystallographic studies, we identify that steroid receptor coactivator-3 (SRC3 ...[more]