Unknown

Dataset Information

0

Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.


ABSTRACT: A subset of CD4?+?lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide variety of cell types. Src-3 knockout mice display broad lymphoproliferation and hypersensitivity to systemic inflammation. Using publicly available bioinformatics data and directed cellular approaches, we show that SRC-3 also is highly enriched in Tregs in mice and humans. Human Tregs lose phenotypic characteristics when SRC-3 is depleted or pharmacologically inhibited, including failure of induction from resting T cells and loss of the ability to suppress proliferation of stimulated T cells. These data support a model for SRC-3 as a coactivator that actively participates in protection from autoimmunity and may support immune evasion of cancers by contributing to the biology of Tregs.

SUBMITTER: Nikolai BC 

PROVIDER: S-EPMC7873281 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs.

Nikolai Bryan C BC   Jain Prashi P   Cardenas David L DL   York Brian B   Feng Qin Q   McKenna Neil J NJ   Dasgupta Subhamoy S   Lonard David M DM   O'Malley Bert W BW  

Scientific reports 20210209 1


A subset of CD4 + lymphocytes, regulatory T cells (Tregs), are necessary for central tolerance and function as suppressors of autoimmunity against self-antigens. The SRC-3 coactivator is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide variety of cell types. Src-3 knockout mice display broad lymphoproliferation and hypersensitivity to systemic inflammation. Using publicly available bioinformatics data and directed cellular approaches, we sho  ...[more]

Similar Datasets

| S-EPMC2998129 | biostudies-literature
| S-EPMC3349901 | biostudies-other
2015-01-21 | E-GEOD-63539 | biostudies-arrayexpress
2015-01-21 | GSE63539 | GEO
| S-EPMC2826835 | biostudies-literature
| S-EPMC22964 | biostudies-literature
| S-EPMC3683811 | biostudies-literature
| S-EPMC2293272 | biostudies-literature
| S-EPMC547886 | biostudies-literature
| S-EPMC5766961 | biostudies-literature