Ontology highlight
ABSTRACT:
SUBMITTER: Goncalves J
PROVIDER: S-EPMC2838703 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Gonçalves João J Gonçalves João J Nolasco Sofia S Nascimento Rute R Lopez Fanarraga Mónica M Zabala Juan Carlos JC Soares Helena H
EMBO reports 20100219 3
In animal cells the centrosome is positioned at the cell centre in close association with the nucleus. The mechanisms responsible for this are not completely understood. Here, we report the first characterization of human TBCC-domain containing 1 (TBCCD1), a protein related to tubulin cofactor C. TBCCD1 localizes at the centrosome and at the spindle midzone, midbody and basal bodies of primary and motile cilia. Knockdown of TBCCD1 in RPE-1 cells caused the dissociation of the centrosome from the ...[more]