Ontology highlight
ABSTRACT:
SUBMITTER: Kelemen JZ
PROVIDER: S-EPMC2838748 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Kelemen János Z JZ Ratna Prasuna P Scherrer Simone S Becskei Attila A
PLoS biology 20100316 3
Bistability in signaling networks is frequently employed to promote stochastic switch-like transitions between cellular differentiation states. Differentiation can also be triggered by antagonism of activators and repressors mediated by epigenetic processes that constitute regulatory circuits anchored to the chromosome. Their regulatory logic has remained unclear. A reaction-diffusion model reveals that the same reaction mechanism can support both graded monostable and switch-like bistable gene ...[more]