Ontology highlight
ABSTRACT:
SUBMITTER: Rowland SL
PROVIDER: S-EPMC2839140 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20100222 3
B cell receptors (BCRs) generate tonic signals critical for B cell survival and early B cell development. To determine whether these signals also mediate the development of transitional and mature B cells, we examined B cell development using a mouse strain in which nonautoreactive immunoglobulin heavy and light chain-targeted B cells express low surface BCR levels. We found that reduced BCR expression translated into diminished tonic BCR signals that strongly impaired the development of transit ...[more]