Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC3538245 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Wang Zhiping Z Liu Yuangang Y Takahashi Maho M Van Hook Kathryn K Kampa-Schittenhelm Kerstin M KM Sheppard Brett C BC Sears Rosalie C RC Stork Philip J S PJ Lopez Charles D CD
Proceedings of the National Academy of Sciences of the United States of America 20121217 1
The ASPP2 (also known as 53BP2L) tumor suppressor is a proapoptotic member of a family of p53 binding proteins that functions in part by enhancing p53-dependent apoptosis via its C-terminal p53-binding domain. Mounting evidence also suggests that ASPP2 harbors important nonapoptotic p53-independent functions. Structural studies identify a small G protein Ras-association domain in the ASPP2 N terminus. Because Ras-induced senescence is a barrier to tumor formation in normal cells, we investigated ...[more]