Ontology highlight
ABSTRACT:
SUBMITTER: Oskeritzian CA
PROVIDER: S-EPMC2839150 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Oskeritzian Carole A CA Price Megan M MM Hait Nitai C NC Kapitonov Dmitri D Falanga Yves T YT Morales Johanna K JK Ryan John J JJ Milstien Sheldon S Spiegel Sarah S
The Journal of experimental medicine 20100301 3
Systemic exacerbation of allergic responses, in which mast cells play a critical role, results in life-threatening anaphylactic shock. Sphingosine-1-phosphate (S1P), a ligand for a family of G protein-coupled receptors, is a new addition to the repertoire of bioactive lipids secreted by activated mast cells. Yet little is known of its role in human mast cell functions and in anaphylaxis. We show that S1P(2) receptors play a critical role in regulating human mast cell functions, including degranu ...[more]