Ontology highlight
ABSTRACT:
SUBMITTER: Kazuki Y
PROVIDER: S-EPMC2839293 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Kazuki Yasuhiro Y Hiratsuka Masaharu M Takiguchi Masato M Osaki Mitsuhiko M Kajitani Naoyo N Hoshiya Hidetoshi H Hiramatsu Kei K Yoshino Toko T Kazuki Kanako K Ishihara Chie C Takehara Shoko S Higaki Katsumi K Nakagawa Masato M Takahashi Kazutoshi K Yamanaka Shinya S Oshimura Mitsuo M
Molecular therapy : the journal of the American Society of Gene Therapy 20091208 2
Human artificial chromosome (HAC) has several advantages as a gene therapy vector, including stable episomal maintenance that avoids insertional mutations and the ability to carry large gene inserts including the regulatory elements. Induced pluripotent stem (iPS) cells have great potential for gene therapy, as such cells can be generated from the individual's own tissues, and when reintroduced can contribute to the specialized function of any tissue. As a proof of concept, we show herein the co ...[more]