Ontology highlight
ABSTRACT:
SUBMITTER: Oliveira C
PROVIDER: S-EPMC2839995 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Oliveira Carla C Suriano Gianpaolo G Ferreira Paulo P Canedo Paulo P Kaurah Pardeep P Mateus Rita R Ferreira Ana A Ferreira António C AC Oliveira Maria José MJ Figueiredo Céu C Carneiro Fátima F Keller Gisela G Huntsman David D Machado José Carlos JC Seruca Raquel R
Hereditary cancer in clinical practice 20040515 2
Approximately 10% of gastric cancer cases show familial clustering but only 1-3% of gastric carcinomas arise as a result of inherited gastric cancer predisposition syndromes. Direct proof that Hereditary Gastric Cancer a genetic disease with a germline gene defect has come from the demonstration of co-segregation of germline E-cadherin (CDH1) mutations with early onset diffuse gastric cancer in families with an autosomal dominant pattern of inheritance (HDGC). E-cadherin is a transmembrane calci ...[more]