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Familial Gastric Cancers.

ABSTRACT: Although the majority of gastric carcinomas are sporadic, approximately 10% show familial aggregation, and a hereditary cause is determined in 1%-3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, genetic counselors, biologists, and pathologists. This article reviews the molecular genetics, clinical and pathologic features, surveillance guidelines, and preventive measures of common and less common hereditary gastric cancer predisposition syndromes.

SUBMITTER: Setia N

PROVIDER: S-EPMC4679084 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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Familial Gastric Cancers.

Setia Namrata N Clark Jeffrey W JW Duda Dan G DG Hong Theodore S TS Kwak Eunice L EL Mullen John T JT Lauwers Gregory Y GY

The oncologist 20150930 12

Although the majority of gastric carcinomas are sporadic, approximately 10% show familial aggregation, and a hereditary cause is determined in 1%-3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, genetic ...[more]

PMID: 26424758

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