Anti-SPARC oligopeptide inhibits laser-induced CNV in mice.
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ABSTRACT:
SUBMITTER: Uehara H
PROVIDER: S-EPMC2840068 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Anti-SPARC oligopeptide inhibits laser-induced CNV in mice.
Uehara Hironori H Luo Ling L Simonis Jacquelyn J Singh Nirbhai N Taylor Ethan Will EW Ambati Balamurali K BK
Vision research 20091222 7
It is known that SPARC gates VEGF-A signal transduction towards KDR, the primary angiogenic VEGF receptor. We sought to determine whether inhibition of SPARC activity using anti-SPARC peptide could inhibit laser-induced CNV by promoting binding of VEGF-A to FLT-1. We created anti-SPARC l-peptide and retro-inverso anti-SPARC d-peptide. Anti-SPARC peptides or PBS were injected intravitreally 1day before or after laser induction. Intravitreal injection of anti-SPARC l-peptide 1day before laser indu ...[more]
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