Ontology highlight
ABSTRACT:
SUBMITTER: Adamson P
PROVIDER: S-EPMC5494198 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Adamson Peter P Wilde Thomas T Dobrzynski Eric E Sychterz Caroline C Polsky Rodd R Kurali Edit E Haworth Richard R Tang Chi-Man CM Korczynska Justyna J Cook Fiona F Papanicolaou Irene I Tsikna Lemy L Roberts Chris C Hughes-Thomas Zoe Z Walford James J Gibson Daniel D Warrack John J Smal Jos J Verrijk Ruud R Miller Paul E PE Nork T Michael TM Prusakiewicz Jeffery J Streit Timothy T Sorden Steven S Struble Craig C Christian Brian B Catchpole Ian R IR
Journal of controlled release : official journal of the Controlled Release Society 20161101 Pt A
A potent anti-vascular endothelial growth factor (VEGF) biologic and a compatible delivery system were co-evaluated for protection against wet age-related macular degeneration (AMD) over a 6month period following a single intravitreal (IVT) injection. The anti-VEGF molecule is dimeric, containing two different anti-VEGF domain antibodies (dAb) attached to a human IgG1 Fc region: a dual dAb. The delivery system is based on microparticles of PolyActive™ hydrogel co-polymer. The molecule was evalua ...[more]