The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication.
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ABSTRACT:
SUBMITTER: Sir D
PROVIDER: S-EPMC2840127 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
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The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication.
Sir Donna D Tian Yongjun Y Chen Wen-ling WL Ann David K DK Yen Tien-Sze Benedict TS Ou Jing-Hsiung James JH
Proceedings of the National Academy of Sciences of the United States of America 20100208 9
Autophagy is a catabolic process by which cells remove long-lived proteins and damaged organelles for recycling. Viral infections may also induce autophagic response. Here we show that hepatitis B virus (HBV), a pathogen that chronically infects approximately 350 million people globally, can enhance autophagic response in cell cultures, mouse liver, and during natural infection. This enhancement of the autophagic response is not coupled by an increase of autophagic protein degradation and is dep ...[more]
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