Ontology highlight
ABSTRACT:
SUBMITTER: Ali SA
PROVIDER: S-EPMC2840145 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Ali Syed A SA Zaidi Sayyed K SK Dobson Jason R JR Shakoori Abdul R AR Lian Jane B JB Stein Janet L JL van Wijnen Andre J AJ Stein Gary S GS
Proceedings of the National Academy of Sciences of the United States of America 20100216 9
Epigenetic control of ribosomal RNA (rRNA) gene transcription by cell type-specific regulators, such as the osteogenic transcription factor Runx2, conveys cellular memory of growth and differentiation to progeny cells during mitosis. Here, we examined whether coregulatory proteins contribute to epigenetic functions that are mitotically transmitted by Runx2 in osteoblastic cells. We show that the transcriptional corepressor Transducin Like Enhancer-1 (TLE1) associates with rRNA genes during mitos ...[more]