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ABSTRACT:
SUBMITTER: Mujtaba S
PROVIDER: S-EPMC2898185 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Mujtaba Shiraz S Manzur Karishma L KL Gurnon James R JR Kang Ming M Van Etten James L JL Zhou Ming-Ming MM
Nature cell biology 20080901 9
Viruses recruit host proteins to secure viral genome maintenance and replication. However, whether they modify host histones directly to interfere with chromatin-based transcription is unknown. Here we report that Paramecium bursaria chlorella virus 1 (PBCV-1) encodes a functional SET domain histone Lys methyltransferase (HKMTase) termed vSET, which is linked to rapid inhibition of host transcription after viral infection. We show that vSET is packaged in the PBCV-1 virion, and that it contains ...[more]