Ontology highlight
ABSTRACT:
SUBMITTER: Vessey JP
PROVIDER: S-EPMC2840302 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Vessey John P JP Schoderboeck Lucia L Gingl Ewald E Luzi Ettore E Riefler Julia J Di Leva Francesca F Karra Daniela D Thomas Sabine S Kiebler Michael A MA Macchi Paolo P
Proceedings of the National Academy of Sciences of the United States of America 20100128 7
In Drosophila, Pumilio (Pum) is important for neuronal homeostasis as well as learning and memory. We have recently characterized a mammalian homolog of Pum, Pum2, which is found in discrete RNA-containing particles in the somatodendritic compartment of polarized neurons. In this study, we investigated the role of Pum2 in developing and mature neurons by RNA interference. In immature neurons, loss of Pum2 led to enhanced dendritic outgrowth and arborization. In mature neurons, Pum2 down-regulati ...[more]