Ontology highlight
ABSTRACT:
SUBMITTER: Freixo F
PROVIDER: S-EPMC5997995 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Freixo Francisco F Martinez Delgado Paula P Manso Yasmina Y Sánchez-Huertas Carlos C Lacasa Cristina C Soriano Eduardo E Roig Joan J Lüders Jens J
Nature communications 20180613 1
Organization of microtubules into ordered arrays is best understood in mitotic systems, but remains poorly characterized in postmitotic cells such as neurons. By analyzing the cycling cell microtubule cytoskeleton proteome through expression profiling and targeted RNAi screening for candidates with roles in neurons, we have identified the mitotic kinase NEK7. We show that NEK7 regulates dendrite morphogenesis in vitro and in vivo. NEK7 kinase activity is required for dendrite growth and branchin ...[more]