Ontology highlight
ABSTRACT:
SUBMITTER: Triantafyllopoulou A
PROVIDER: S-EPMC2840310 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Triantafyllopoulou Antigoni A Franzke Claus-Werner CW Seshan Surya V SV Perino Giorgio G Kalliolias George D GD Ramanujam Meera M van Rooijen Nico N Davidson Anne A Ivashkiv Lionel B LB
Proceedings of the National Academy of Sciences of the United States of America 20100126 7
Glomerulonephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Although substantial progress has been made in the identification of pathogenic triggers that result in autoantibody production, little is known about the pathogenesis of aggressive proliferative processes that lead directly to irreversible glomerular damage and compromise of renal function. In this study, we describe a model of polyinosinic: polycytidylic acid-accelerated lupus nephritis in NZB/W mic ...[more]