Ontology highlight
ABSTRACT:
SUBMITTER: Goldschmidt L
PROVIDER: S-EPMC2840437 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Goldschmidt Lukasz L Teng Poh K PK Riek Roland R Eisenberg David D
Proceedings of the National Academy of Sciences of the United States of America 20100203 8
The amylome is the universe of proteins that are capable of forming amyloid-like fibrils. Here we investigate the factors that enable a protein to belong to the amylome. A major factor is the presence in the protein of a segment that can form a tightly complementary interface with an identical segment, which permits the formation of a steric zipper-two self-complementary beta sheets that form the spine of an amyloid fibril. Another factor is sufficient conformational freedom of the self-compleme ...[more]