Prolonged sensory-selective nerve blockade.
Ontology highlight
ABSTRACT:
SUBMITTER: Sagie I
PROVIDER: S-EPMC2840479 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Prolonged sensory-selective nerve blockade.
Sagie Itay I Kohane Daniel S DS
Proceedings of the National Academy of Sciences of the United States of America 20100204 8
Sensory-selective local anesthesia has long been a key goal in local anesthetic development. For example, it allows women to be pain-free during labor without compromising their ability to push. Here we show that prolonged sensory-selective nerve block can be produced by specific concentrations of surfactants-such as are used to enhance drug flux across skin-in combination with QX-314, a lidocaine derivative that has relative difficulty penetrating nerves. For example, injection of 25 mM QX-314 ...[more]
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