Ontology highlight
ABSTRACT:
SUBMITTER: Yasukochi Y
PROVIDER: S-EPMC2840519 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Yasukochi Yukio Y Maruyama Osamu O Mahajan Milind C MC Padden Carolyn C Euskirchen Ghia M GM Schulz Vincent V Hirakawa Hideki H Kuhara Satoru S Pan Xing-Hua XH Newburger Peter E PE Snyder Michael M Weissman Sherman M SM
Proceedings of the National Academy of Sciences of the United States of America 20100202 8
The DNA methylation status of human X chromosomes from male and female neutrophils was identified by high-throughput sequencing of HpaII and MspI digested fragments. In the intergenic and intragenic regions on the X chromosome, the sites outside CpG islands were heavily hypermethylated to the same degree in both genders. Nearly half of X chromosome promoters were either hypomethylated or hypermethylated in both females and males. Nearly one third of X chromosome promoters were a mixture of hypom ...[more]