Epigenome-wide analyses identify DNA methylation signatures of dementia risk.
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ABSTRACT:
SUBMITTER: Walker RM
PROVIDER: S-EPMC7416667 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Epigenome-wide analyses identify DNA methylation signatures of dementia risk.
Walker Rosie M RM Bermingham Mairead L ML Vaher Kadi K Morris Stewart W SW Clarke Toni-Kim TK Bretherick Andrew D AD Zeng Yanni Y Amador Carmen C Rawlik Konrad K Pandya Kalyani K Hayward Caroline C Campbell Archie A Porteous David J DJ McIntosh Andrew M AM Marioni Riccardo E RE Evans Kathryn L KL
Alzheimer's & dementia (Amsterdam, Netherlands) 20200810 1
<h4>Introduction</h4>Dementia pathogenesis begins years before clinical symptom onset, necessitating the understanding of premorbid risk mechanisms. Here we investigated potential pathogenic mechanisms by assessing DNA methylation associations with dementia risk factors in Alzheimer's disease (AD)-free participants.<h4>Methods</h4>Associations between dementia risk measures (family history, AD genetic risk score [GRS], and dementia risk scores [combining lifestyle, demographic, and genetic facto ...[more]
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